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BACE2 (基因名), Beta-secretase 2 (蛋白名), bace2_human.
产品名称:

Human BACE2/ Beta-secretase 2 Recombinant Protein
β分泌酶2

货号:

R1812h

商标:
EIAab®
监管等级:
别名:

Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, ASP1, Beta-site APP cleaving enzyme 2, DRAP, CDA13, UNQ418/PRO852, AEPLC, ALP56, ASP21

序列号:
Q9Y5Z0
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human BACE2 Protein
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Human BACE2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 21q22.2-q22.3 by HGNC 21q22.2-q22.3 by Entrez Gene 21q22.2-q22.3 by Ensembl
BACE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer. Interacts ith RTN3 and RTN4.


功能:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.


亚细胞位置:
Membrane Single-pass type I membrane protein Golgi apparatus Endoplasmic reticulum Endosome Cell surface


该产品尚未在任何出版物中被引用。

[1].
"A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase."

[2].
"Lack of association between the polymorphisms of beta-site APP-cleaving enzyme 2 (BACE2) 5'-flanking region and sporadic Alzheimer's disease."

[3].
"Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor."

[4].
"BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome."

[5].
"Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein."

[6].
"Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes."

[7].
"Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers."

[8].
"Prodomain processing of Asp1 (BACE2) is autocatalytic."

[9].
"BACE2 functions as an alternative alpha-secretase in cells."

[10].
"The DNA sequence of human chromosome 21."
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