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ARAP3 (基因名), Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (蛋白名), arap3_human.
产品名称:

Human ARAP3/ Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Centaurin-delta-3, Cnt-d3, CENTD3

序列号:
Q8WWN8
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ARAP3 Protein
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Human ARAP3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 5q31.3 by HGNC 5q31.3 by Entrez Gene 5q31.3 by Ensembl
ARAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts (via SAM domain) with INPPL1/SHIP2.


功能:
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.


亚细胞位置:
Cytoplasm Cytoplasm Cytoskeleton Cell membrane Peripheral membrane protein Cell projection Lamellipodium Cell projection Ruffle Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia.


该产品尚未在任何出版物中被引用。

[1].
"Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices."

[2].
"EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin."

[3].
"GTPase signaling: bridging the GAP between ARF and Rho."

[4].
"The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner."

[5].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[6].
"Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3."

[7].
"Phospho-tyrosine dependent protein-protein interaction network."

[8].
"Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation."

[9].
"A human interactome in three quantitative dimensions organized by stoichiometries and abundances."

[10].
"A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning."
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