首页 > 重组蛋白 > Human AQP4 Recombinant Protein

AQP4 (基因名), Aquaporin-4 (蛋白名), aqp4_human.

产品名称:

Human AQP4/ Aquaporin-4 Recombinant Protein
水通道蛋白4

货号:

R0582h

商标:

EIAab^®

监管等级:

RUO

别名:

Mercurial-insensitive water channel, WCH4, MIWC, AQP-4

序列号:

P55087

来源:

E.coli

种属:

Human

标签:

His

序列:

216-315aa

预估分子量:

11.0 kDa (monomer)

纯度:

Greater than 95% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human AQP4 Protein

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产品说明书

说明书:

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文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The sequence analysis of human AQP4 protein including hydrophilcity, hydrophobicity and antigenicity.

Recombinant human AQP4 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 18q11.2 by HGNC 18q11.2 by Entrez Gene 18q11.2 by Ensembl

AQP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homotetramer (PubMed:19383790). The tetramers can form oligomeric arrays in membranes. The size of the oligomers differs between tissues and is smaller in skeletal muscle than in brain. Interaction between AQP4 oligomeric arrays in close-by cells can contribute to cell-cell adhesion (By similarity). Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1 (PubMed:22328087).

功能:

Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).

亚细胞位置:

Cell membrane Multi-pass membrane protein Basolateral cell membrane Multi-pass membrane protein Endosome membrane Cell membrane Sarcolemma Multi-pass membrane protein Cell projection Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries.

数据库链接

UniGene:

Hs.315369

SMR:

P55087

STRING:

9606.ENSP00000372654

KEGG:

hsa:361

MIM:

600308

Pfam:

PF00230

Uniprot:

P55087

相关产品

Mouse Aqp4 ELISA Kit

Rat Aqp4 ELISA Kit

Bovine AQP4 ELISA Kit

Mouse Aqp4 CLIA Kit

Rat Aqp4 CLIA Kit

序列长度:

323

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

328:

GVVH VIDVD | RGEEKKGKDQ | SGEVLSSV

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy."

(PMID: 19864112)

[2].

"Investigating the genetic role of aquaporin4 gene in migraine."

(PMID: 19209385)

[3].

"The role of aquaporin-4 polymorphisms in the development of brain edema after middle cerebral artery occlusion."

(PMID: 18309154)

[4].

"Can variation in aquaporin 4 gene be associated with different outcomes in traumatic brain edema?"

(PMID: 17890008)

[5].

"Linkage disequilibrium in aquaporin 4 gene and association study with schizophrenia."

(PMID: 16194264)

[6].

"Beyond water channel: aquaporin-4 in adult neurogenesis."

(PMID: 20138100)

[7].

"Molecular analysis of aquaporin genes 1 to 4 in patients with Menière's disease."

(PMID: 21063116)

[8].

"Differential expression of aquaporin-4 isoforms localizes with neuromyelitis optica disease activity."

(PMID: 20227773)

[9].

"Aquaporin expression in normal and pathological skeletal muscles: a brief review with focus on AQP4."

(PMID: 20339523)

[10].

"Aquaporin-4 gene variation and sudden infant death syndrome."

(PMID: 20351659)

[1].

人水通道蛋白4(AQP4)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人水通道蛋白4(AQP4)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人水通道蛋白4(AQP4)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人水通道蛋白4(AQP4)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人水通道蛋白4(AQP4)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人水通道蛋白4(AQP4)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人水通道蛋白4(AQP4)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人水通道蛋白4(AQP4)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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