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SERPINC1 (基因名), Antithrombin-III (蛋白名), ant3_human.
产品名称:

Human SERPINC1/ Antithrombin-III Recombinant Protein
抗凝血酶III

货号:

R0878h

商标:
EIAab®
监管等级:
别名:

Serpin C1, PRO0309, ATIII, AT3

序列号:
P01008
来源:
E.coli
种属:
Human
标签:
His
序列:
33-464aa
预估分子量:
47.52 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SERPINC1 Protein
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Human SERPINC1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human SERPINC1 Protein
Recombinant human SERPINC1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 1q25.1 by HGNC 1q25.1 by Entrez Gene 1q25.1 by Ensembl
SERPINC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Forms protease inhibiting heterodimer with TMPRSS7.


功能:
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.


亚细胞位置:
Secreted Extracellular space


该产品尚未在任何出版物中被引用。

[1].
"Molecular basis of inherited antithrombin deficiency in Portuguese families: identification of genetic alterations and screening for additional thrombotic risk factors."

[2].
"Antithrombin Phe229Leu: a new homozygous variant leading to spontaneous antithrombin polymerization in vivo associated with severe childhood thrombosis."

[3].
"Antithrombin 'DREUX' (Lys 114Glu): a variant with complete loss of heparin affinity."

[4].
"Antithrombin III Kumamoto II; a single mutation at Arg393-His increased the affinity of antithrombin III for heparin."

[5].
"Three novel missense mutations in the antithrombin III (AT3) gene causing recurrent venous thrombosis."

[6].
"The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions."

[7].
"Biological implications of a 3 A structure of dimeric antithrombin."

[8].
"Antithrombin III Nagasaki (Ser116-Pro): a heterozygous variant with defective heparin binding associated with thrombosis."

[9].
"Complete nucleotide sequence of the antithrombin gene: evidence for homologous recombination causing thrombophilia."

[10].
"Antithrombin-III-Stockholm: a codon 392 (Gly----Asp) mutation with normal heparin binding and impaired serine protease reactivity."
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