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首页  >  重组蛋白  >  Human ANGPT2 Recombinant Protein
ANGPT2 (基因名), Angiopoietin-2 (蛋白名), angp2_human.
产品名称:

Human ANGPT2/ Angiopoietin-2 Recombinant Protein
血管生成素

货号:

R0009h

商标:
EIAab®
监管等级:
别名:

ANG-2

序列号:
O15123
来源:
E.coli
种属:
Human
标签:
His
序列:
275-495aa
预估分子量:
24.31 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ANGPT2 Protein
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Human ANGPT2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 8p23.1 by HGNC 8p23.1 by Entrez Gene 8p23.1 by Ensembl
ANGPT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.


功能:
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.


亚细胞位置:
Secreted



[1].
Yesildal F, Koc E, Tas A, et al.

[1].
"Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium."

[2].
"Biological characterization of angiopoietin-3 and angiopoietin-4."

[3].
"Maternal serum angiopoietin-1 and -2 and tie-2 in early pregnancy ending in preeclampsia or intrauterine growth retardation."

[4].
"Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface."

[5].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[6].
"Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes."

[7].
"A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)."

[8].
"Promoter variant of angiopoietin-2 and plasma angiopoietin-2 are associated with risk of stroke recurrence in lacunar infarct patients."

[9].
"Angiopoietin-2 promotes disease progression of neuroendocrine tumors."

[10].
"Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study-74)."
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