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ADRB1 (基因名), Beta-1 adrenergic receptor (蛋白名), adrb1_human1.
产品名称:

Human ADRB1/ Beta-1 adrenergic receptor Recombinant Protein
β肾上腺素受体

货号:

R10653h

商标:
EIAab®
监管等级:
别名:

Beta-1 adrenoreceptor, Beta-1 adrenoceptor, ADRB1R, B1AR

序列号:
P08588
来源:
E.coli
种属:
Human
标签:
His
序列:
399-477aa
预估分子量:
8.69 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ADRB1 Protein
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Human ADRB1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human ADRB1 Protein
Recombinant human ADRB1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 10q25.3 by HGNC 10q25.3 by Entrez Gene 10q25.3 by Ensembl
ADRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4.


功能:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.


亚细胞位置:
Cell membrane Multi-pass membrane protein Early endosome Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.


该产品尚未在任何出版物中被引用。

[1].
"A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate."

[2].
"Relationship between beta1-adrenergic receptor polymorphisms and cardiovascular disease in patients with diabetic nephropathy."

[3].
"Association of ADRB1 gene polymorphism with atrial fibrillation."

[4].
"Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure."

[5].
"Polymorphisms of the beta1-adrenergic receptor gene are associated with essential hypertension in Chinese."

[6].
"Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade."

[7].
"Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival."

[8].
"Genetic polymorphisms of beta1 adrenergic receptor and their influence on the cardiovascular responses to metoprolol in a South Indian population."

[9].
"Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome."

[10].
"beta-adrenergic receptor gene polymorphisms and beta-blocker treatment outcomes in hypertension."
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