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AATF (基因名), Protein AATF (蛋白名), AATF_HUMAN.
产品名称:

Human AATF/ Protein AATF Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, CHE1, DED, HSPC277

来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human AATF Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 17q12 by HGNC 17q12 by Entrez Gene 17q12 by Ensembl
AATF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


Sub Unit:
Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT.


Function:
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.


Subcellular Location:
Nucleus Nucleolus


该产品尚未在任何出版物中被引用。

[1].
"Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb."

[2].
"AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4."

[3].
"AATF protects neural cells against oxidative damage induced by amyloid beta-peptide."

[4].
"Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis."

[5].
"Identification of novel transcription factor-like gene from human intestinal cells."

[6].
"Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes."

[7].
"Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging."

[8].
"Mutation analysis of the AATF gene in breast cancer families."

[9].
"Functional characterization of AATF transcriptome in human leukemic cells."

[10].
"NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death."
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