027-59234612(+86)
EIAab
首页  >  重组蛋白  >  Human A2ML1 Recombinant Protein
A2ML1 (基因名), Alpha-2-macroglobulin-like protein 1 (蛋白名), A2ML1_HUMAN.
产品名称:

Human A2ML1/ Alpha-2-macroglobulin-like protein 1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9, CPAMD9

来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human A2ML1 Protein
规格 & 价格: 登录.
×
Human A2ML1 Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 12p13.31 by HGNC 12p13.31 by Entrez Gene 12p13.31 by Ensembl
A2ML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


Sub Unit:
Monomer.


Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.


Subcellular Location:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis."

[2].
"Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease."

[3].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[4].
"Architecture of the human interactome defines protein communities and disease networks."

[5].
"Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline."

[6].
"Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population."

[7].
"Middle ear microbiome differences in indigenous Filipinos with chronic otitis media due to a duplication in the A2ML1 gene."

[8].
"Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome."

[9].
"Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes."

[10].
"External ear anomalies and hearing impairment in Noonan Syndrome."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
消息
close_message
产品名称 *
邮箱 *
消息 *
通知
new 留 言
规格 数量 价格 ($) 小计 1 ($)
小计 2: $
triangle
规格 数量 价格 ($)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59759960(+86)
邮箱:sales@eiaab.com