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首页  >  重组蛋白  >  Human NUDT1 Recombinant Protein
NUDT1 (基因名), 7,8-dihydro-8-oxoguanine triphosphatase (蛋白名), 8ODP_HUMAN.
产品名称:

Human NUDT1/ 7,8-dihydro-8-oxoguanine triphosphatase Recombinant Protein
7,8-二氢-8氧桥鸟嘌呤三磷酸

货号:

R3104h

商标:
EIAab®
监管等级:
别名:

2-hydroxy-dATP diphosphatase, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1, MTH1

来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human NUDT1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 7p22.3 by HGNC 7p22.3 by Entrez Gene 7p22.3 by Ensembl
NUDT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


Sub Unit:
Monomer.


Function:
Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.


Subcellular Location:
Isoform p26 Cytoplasm Mitochondrion matrix


该产品尚未在任何出版物中被引用。

[1].
"Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk."

[2].
"Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus."

[3].
"Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis."

[4].
"Association study of human MTH1 Ile45Thr polymorphism with sporadic Parkinson's disease."

[5].
"Analysis of the base excision repair genes MTH1, OGG1 and MUTYH in patients with squamous oral carcinomas."

[6].
"MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas."

[7].
"Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer."

[8].
"Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis."

[9].
"The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal."

[10].
"Germline susceptibility to colorectal cancer due to base-excision repair gene defects."
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