HTR1B (基因名), 5-hydroxytryptamine receptor 1B (蛋白名), 5HT1B_PIG.
Pig HTR1B/ 5-hydroxytryptamine receptor 1B Recombinant Protein
5-HT-1B, Serotonin receptor 1B
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Homodimer. Heterodimer with HTR1D.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Cell membrane Multi-pass membrane protein
"Lack of association between five serotonin metabolism-related genes and medication overuse headache."
"[Association study of HTR1A and HTR1B with adolescent idiopathic scoliosis]."
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."
"Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder."
"Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men."
"SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A."
"An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population."
"Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder."
"The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence."
"HTR1B and HTR2C in autism spectrum disorders in Brazilian families."
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