HTR1A (基因名), 5-hydroxytryptamine receptor 1A (蛋白名), 5HT1A_CANLF.
Dog HTR1A/ 5-hydroxytryptamine receptor 1A Recombinant Protein
5-HT-1A, Serotonin receptor 1A
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Heterodimer; heterodimerizes with GPER1.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Cell membrane Multi-pass membrane protein
MEGLSPRQGN | NTTSSEGPFG | TLGNATGISD | VTFSYQVITS | LLLGTLIFCA |
VLGNACVVAA | IALERSLQNV | ANYLIGSLAV | TDLMVSVLVL | PMAALYQVLN |
KWTLGQVTCD | LFIALDVLCC | TSSILHLCAI | ALDRYWAITD | PIDYVNKRTP |
RRAAALISLT | WLIGFLISIP | PMLGWRTPED | RSDPDACTIS | KDHGYTIYST |
FGAFYIPLLL | MLVLYGRIFR | AARFRIRKTV | KKAERKGADA | RSGVSPAPQP |
RKSVNGEPGG | REWRQGPGSQ | AGGPLCTNGA | VRRGDDGAAL | EVIEVHRVGS |
SKEHLPLPCE | AGAIPCAPAS | FEKKNERNAE | AKRKMALARE | RKTVKTLGII |
MGTFILCWLP | FFIVALVLPF | CESSCHMPTL | LGAIINWLGY | SNSLLNPVIY |
AYFNKDFQNA | FKKIVRCKFC | RRR
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."
"SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A."
"Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder."
"Interaction between genetic polymorphisms and stressful life events in first episode depression."
"Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression."
"Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes."
"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response."
"Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia."
"Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders."
"Association between 5-hydroxytryptamine 1A receptor gene polymorphism and suicidal behavior."
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