027-59234612(+86)
EIAab
首页  >  重组蛋白  >  Human EIF4EBP2 Recombinant Protein
EIF4EBP2 (基因名), Eukaryotic translation initiation factor 4E-binding protein 2 (蛋白名), 4EBP2_HUMAN.
产品名称:

Human EIF4EBP2/ Eukaryotic translation initiation factor 4E-binding protein 2 Recombinant Protein

货号:

R2694h

商标:
EIAab®
监管等级:
别名:

4E-BP2

来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human EIF4EBP2 Protein
规格 & 价格: 登录.
×
Human EIF4EBP2 Protein
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 10q22.1 by HGNC 10q22.1 by Entrez Gene 10q22.1 by Ensembl
EIF4EBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


Sub Unit:
Hypophosphorylated EIF4EBP2 interacts with EIF4E; phosphorylation of EIF4EBP2 by mTORC1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:7935836, PubMed:24207126, PubMed:21661078, PubMed:25533957). Interacts with RPTOR; promoting phosphorylation by mTORC1 (By similarity). Interacts with PCMT1; required to prevent isoaspartate accumulation and convert isoaspartate to Asp.


Function:
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.


Subcellular Location:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2."

[2].
"Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function."

[3].
"Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch."

[4].
"Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface."

[5].
"Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1."

[6].
"Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission."

[7].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[8].
"Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"."

[9].
"Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis."

[10].
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
消息
close_message
产品名称 *
邮箱 *
消息 *
通知
new 留 言
规格 数量 价格 ($) 小计 1 ($)
小计 2: $
triangle
规格 数量 价格 ($)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59759960(+86)
邮箱:sales@eiaab.com