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HSD3B7 (基因名), 3 beta-hydroxysteroid dehydrogenase type 7 (蛋白名), 3BHS7_HUMAN.
产品名称:

Human HSD3B7/ 3 beta-hydroxysteroid dehydrogenase type 7 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

3 beta-hydroxysteroid dehydrogenase type VII, 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase, Cholest-5-ene-3-beta, 7-alpha-diol 3-beta-dehydrogenase, 3-beta-HSD VII, C(27) 3-beta-HSD

序列号:
Q9H2F3
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human HSD3B7 Protein
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Human HSD3B7 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 16p11.2 by HGNC 16p11.2 by Entrez Gene 16p11.2 by Ensembl
HSD3B7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.


亚细胞位置:
Endoplasmic reticulum membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease."

[2].
"The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis."

[3].
"The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative."

[4].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"Novel Mutations in the 3β-hydroxy-?5-C27-steroid Dehydrogenase Gene (HSD3B7) in a Patient with Neonatal Cholestasis."

[7].
"Expression of steroid sulfated transporters and 3β-HSD activity in endometrium of women having polycystic ovary syndrome."

[8].
"A proteome-scale map of the human interactome network."

[9].
"Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology."

[10].
"Insights into RNA biology from an atlas of mammalian mRNA-binding proteins."
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