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YWHAH (基因名), 14-3-3 protein eta (蛋白名), 1433F_HUMAN.
产品名称:

Human YWHAH/ 14-3-3 protein eta Recombinant Protein
14-3-3蛋白埃塔

货号:

R14292h

商标:
EIAab®
监管等级:
别名:

Protein AS1, YWHA1

序列号:
Q04917
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human YWHAH Protein
规格 & 价格: cart
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Human YWHAH Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 22q12.3 by HGNC 22q12.3 by Entrez Gene 22q12.3 by Ensembl
YWHAH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509).


功能:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia."

[2].
"14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia."

[3].
"The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions."

[4].
"cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain."

[5].
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."

[6].
"Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study."

[7].
"Family-based association of YWHAH in psychotic bipolar disorder."

[8].
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."

[9].
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."

[10].
"Structural basis for protein-protein interactions in the 14-3-3 protein family."
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