YWHAB (基因名), 14-3-3 protein beta/alpha (蛋白名), 1433B_HUMAN.
Human YWHAB/ 14-3-3 protein beta/alpha Recombinant Protein
Protein 1054, Protein kinase C inhibitor protein 1, KCIP-1
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
(Microbial infection) Interacts with herpes simplex virus 1 protein UL46.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Cytoplasm Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
MTMDKSELVQ | KAKLAEQAER | YDDMAAAMKA | VTEQGHELSN | EERNLLSVAY |
KNVVGARRSS | WRVISSIEQK | TERNEKKQQM | GKEYREKIEA | ELQDICNDVL |
ELLDKYLIPN | ATQPESKVFY | LKMKGDYFRY | LSEVASGDNK | QTTVSNSQQA |
YQEAFEISKK | EMQPTHPIRL | GLALNFSVFY | YEILNSPEKA | CSLAKTAFDE |
AIAELDTLNE | ESYKDSTLIM | QLLRDNLTLW | TSENQGDEGD | AGEGEN
"Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils."
"Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding."
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."
"A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection."
"A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activation."
"Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons."
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
"Examination of association to autism of common genetic variationin genes related to dopamine."
"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control."
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