Hamp (基因名), Hepcidin (蛋白名), 10706_EIAAB.
Mouse Hamp/ Hepcidin Recombinant Protein
Hamp1, Hepc, Hepc1
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
"HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype."
"Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major."
"Mutations in HAMP and HJV genes and their impact on expression of clinical hemochromatosis in a cohort of 100 Spanish patients homozygous for the C282Y mutation of HFE gene."
"Non-classical hereditary hemochromatosis in Portugal: novel mutations identified in iron metabolism-related genes."
"Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance."
"Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis."
"The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis."
"A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload."
"Hepcidin, a urinary antimicrobial peptide synthesized in the liver."
"LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity."
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