PCT (短名 ),
Dog PCT/ Procalcitonin Recombinant Protein
12.76 kDa (monomer)
Greater than 90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Recombinant dog PCT protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
The level of procalcitonin in the blood stream of healthy individuals is below the limit of detection (10 pg/mL) of clinical assays. The level of procalcitonin raises in a response to a proinflammatory stimulus, especially of bacterial origin. In this case, it is produced mainly by the cells of the lung and the intestine. It does not raise significantly with viral or non-infectious inflammations. With the derangements that a severe infection with an associated systemic response brings, the blood levels of procalcitonin may rise to 100 ng/ml. In serum, procalcitonin has a half-life of 25 to 30 hours. Remarkably the high procalcitonin levels produced during infections are not followed by a parallel increase in calcitonin or serum calcium levels.
Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It is composed of 116 amino acids and is produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine.
Xiaotian Chang · Yan Zhao · Shui Sun ·Yunzhong Zhang · Youming Zhu
From: Rheumatol Int
Qian Ran, Ping Hao, Yanni Xiao, Jiang Zhao, Xingde Ye, Zhongjun Li
From: AM SCI
ANK Floras, MK Holowaychuk
From: Journal of Veterinary
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