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YAP1 (基因名), Transcriptional coactivator YAP1 (蛋白名), yap1_human.

产品名称:

YAP1 Antibody

货号:

P15210Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Protein yorkie homolog, Yes-associated protein YAP65 homolog, Yes-associated protein 1, YAP65

序列号:

P46937

反应性:

human, mouse, zebrafish

免疫原:

( )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human YAP1 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical of paraffin-embedded human ovary tumor using YAP1 antibody at dilution of 1:100.

通用注释

亚单元:

Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2 (PubMed:9202023). Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif (By similarity). The phosphorylated form interacts with YWHAB (PubMed:17974916). Interacts (via WW domains) with LATS1 (via PPxY motif 2) (PubMed:18158288). Interacts with LATS2 (PubMed:18158288). Isoform 2 and isoform 3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2) (PubMed:12807903). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (PubMed:18579750, PubMed:20123905, PubMed:20123908). Interacts with TP73 (PubMed:18280240). Interacts with RUNX1 (PubMed:18280240). Interacts with HCK (PubMed:17535448). Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity (PubMed:22525271).

功能:

Isoform 2: Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).

亚细胞位置:

Cytoplasm Nucleus Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271).

数据库链接

UniGene:

Hs.503692

SMR:

P46937

STRING:

9606.ENSP00000282441

KEGG:

hsa:10413

MIM:

120433

Pfam: