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VHL (基因名), Von Hippel-Lindau disease tumor suppressor (蛋白名), vhl_human.

产品名称:

VHL Antibody

货号:

P1894Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Protein G7, pVHL

序列号:

P40337

反应性:

human,mouse,rat

免疫原:

corresponding to a sequence mapping at the 1-213aa of P40337

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human VHL Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

VHL antibody detects VHL protein at cytosol on mouse kidney by immunohistochemical analysis. Sample: Paraffinembedded mouse kidney VHL antibody dilution: 1:200.

通用注释

亚单元:

Component of the VCB (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome-dependent degradation of targeted proteins. Interacts with CUL2; this interaction is dependent on the integrity of the trimeric VBC complex. Interacts (via the beta domain) with HIF1A (via the NTAD domain); this interaction mediates degradation of HIF1A in normoxia and, in hypoxia, prevents ubiquitination and degradation of HIF1A by mediating hypoxia-induced translocation to the nucleus, a process which requires a hypoxia-dependent regulatory signal. Interacts with ADRB2; the interaction, in normoxia, is dependent on hydroxylation of ADRB2 and the subsequent VCB-mediated ubiquitination and degradation of ADRB2. Under hypoxia, hydroxylation, interaction with VHL, ubiquitination and subsequent degradation of ADRB2 are dramatically decreased. Interacts with RNF139, USP33 and JADE1. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Isoform 1 and isoform 3 interact with LIMD1 (via LIM zinc-binding 2), AJUBA (via LIM domains) and WTIP (via LIM domains). Interacts with EPAS1. Interacts with CARD9.

功能:

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.

亚细胞位置:

Isoform 3 Cytoplasm Nucleus Equally distributed between the nucleus and the cytoplasm but not membrane-associated.

数据库链接

UniGene:

Hs.517792

SMR:

P40337

STRING:

9606.ENSP00000256474

KEGG:

hsa:7428

MIM: