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VEGFA (基因名), Vascular endothelial growth factor A (蛋白名), vegfa_human.
产品名称:

VEGFA Antibody

货号:

P0143Rb-h

商标:
EIAab®
监管等级:
别名:

Vascular permeability factor, VPF, VEGF-A, VEGF

序列号:
P15692
反应性:
human,mouse
免疫原:
Recombinant mouse VEGFA Protein (R0143m)
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Cancer
  • Human VEGFA Polyclonal Antibody
  • Human VEGFA Polyclonal Antibody
  • Human VEGFA Polyclonal Antibody
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Human VEGFA Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
Human VEGFA Polyclonal Antibody
Immunohistochemical staining of human lung carcinoma tissue using VEGF antibody dilution at 1:0.
通用注释


亚单元:
Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (PubMed:26503042).


功能:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development.


亚细胞位置:
Secreted VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.


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