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TLR1 (基因名), Toll-like receptor 1 (蛋白名), tlr1_human.

产品名称:

TLR1 Antibody

货号:

P1988Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Toll/interleukin-1 receptor-like protein, TIL, CD281, KIAA0012

序列号:

Q15399

反应性:

human,mouse,rat

免疫原:

Recombinant human TLR1 protein ( R1988h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human TLR1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical staining of mouse spleen tissue using a TLR1 Receptor 1 polyclonal antibody.

通用注释

亚单元:

Interacts (via extracellular domain) with TLR2. TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211, PubMed:17889651). The activation cluster TLR2:TLR1:CD14 forms in response to triacylated lipopeptides (PubMed:16880211). Binds MYD88 (via TIR domain). Interacts with CNPY3.

功能:

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

亚细胞位置:

Cell membrane Single-pass type I membrane protein Cytoplasmic vesicle Phagosome membrane Single-pass type I membrane protein Membrane raft Golgi apparatus Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.

数据库链接

UniGene:

Hs.621817

SMR:

Q15399

STRING:

9606.ENSP00000354932

KEGG:

hsa:7096

MIM:

601194

Pfam: