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RIPK3 (基因名), Receptor-interacting serine/threonine-protein kinase 3 (蛋白名), ripk3_human.

产品名称:

RIPK3 Antibody

货号:

P11168Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIP3

序列号:

Q9Y572

反应性:

human

免疫原:

Recombinant human RIPK3 protein ( R11168h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Immunology

规格 & 价格:

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Human RIPK3 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

RIPK3 antibody detects RIP3 protein at cytoplasm in human colon by immunohistochemical analysis. Sample: Paraffin-embedded human colon. RIKP3 antibody diluted at 1:200.

通用注释

亚单元:

Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts with MLKL; the interaction is direct. Binds TRAF2 and is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with ARHGEF2.

功能:

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

亚细胞位置:

Cytoplasm Cytosol Cell membrane Mitochondrion

数据库链接

UniGene:

Hs.268551

SMR:

Q9Y572

STRING:

9606.ENSP00000216274

KEGG:

hsa:11035

MIM: