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RGMA (基因名), Repulsive guidance molecule A (蛋白名), rgma_human.
产品名称:

RGMA Antibody

货号:

P3256Rb

商标:
EIAab®
监管等级:
别名:

RGM domain family member A, RGM

序列号:
Q96B86
反应性:
human,mouse,rat
免疫原:
Recombinant human RGMA protein ( R3256h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Neurosciences
Human RGMA Polyclonal Antibody
规格 & 价格: cart
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Human RGMA Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical analysis of formalin-fixed paraffin embedded Mouse embryos tissue using RGMA antibody (dilution at 1:100).
通用注释


亚单元:
Interacts with NEO1, BMP2 and BMP4.


功能:
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.


亚细胞位置:
Cell membrane Lipid-anchor GPI-anchor


该产品尚未在任何出版物中被引用。
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