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RNF7 (基因名), RING-box protein 2 (蛋白名), rbx2_human.

产品名称:

RNF7 Antibody

货号:

P11416Rb

商标:

EIAab^®

监管等级:

RUO

别名:

CKII beta-binding protein 1, RING finger protein 7, Regulator of cullins 2, Sensitive to apoptosis gene protein, CKBBP1, Rbx2, RBX2, ROC2, SAG

序列号:

Q9UBF6

反应性:

human,mouse,rat

免疫原:

Recombinant human RNF7 protein ( R11416h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human RNF7 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemistry-Paraffin: RNF7 Antibody - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

通用注释

亚单元:

Probable part of SCF complexes, which consist of SKP1, CUL1, RNF7/RBX2 and a F-box protein. Interacts (preferentially) with CUL5. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B. Interacts with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2.

功能:

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.

亚细胞位置:

Cytoplasm Nucleus

数据库链接

UniGene:

Hs.134623

SMR:

Q9UBF6

STRING:

9606.ENSP00000273480

KEGG:

hsa:9616

MIM: