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RAP1A (基因名), Ras-related protein Rap-1A (蛋白名), rap1a_human.

产品名称:

RAP1A Antibody

货号:

P3220Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

C21KG, G-22K, GTP-binding protein smg p21A, Ras-related protein Krev-1, KREV1

序列号:

P62834

反应性:

human

免疫原:

Recombinant human RAP1A protein ( R3220h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human RAP1A Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical staining of human pancreas using RAP1A antibody shows strong cytoplasmic positivity in Islet cells and moderate cytoplasmic staining in exocrine glands.

通用注释

亚单元:

Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain).

功能:

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

亚细胞位置:

Cell membrane Lipid-anchor Cytoplasm Cytoplasm Perinuclear region Cell junction Early endosome Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region.

数据库链接

UniGene:

Hs.190334

SMR:

P62834

STRING:

9606.ENSP00000348786

KEGG:

hsa:5906

MIM:

179520

Pfam: