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PKD2 (基因名), Polycystin-2 (蛋白名), pkd2_human.

产品名称:

PKD2 Antibody

货号:

P14978Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, Transient receptor potential cation channel subfamily P member 2, PC2, TRPP2

序列号:

Q13563

反应性:

human

免疫原:

corresponding to a sequence mapping at the 266-375aa of Q13563

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cardiovascular

规格 & 价格:

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Human PKD2 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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常见问题解答
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R&D 技术数据

Western Blot: PKD2 Antibody - PKD2 monoclonal antibody . Analysis of PKD2 expression in human liver.

Immunohistochemistry: PKD2 Antibody - Sample: FFPE section of human testicular seminoma. Antibody at a dilution of 1:100. Detection: DAB.

通用注释

亚单元:

Forms homooligomers. Isoform 1 interacts with PKD1 while isoform 3 does not (By similarity). Interacts with PKD1L1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP (PubMed:10913159). Interacts with HAX1 (PubMed:10760273). Interacts with NEK8 (By similarity). Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C (By similarity). Interacts (via C-terminus) with TRPV4 (via C-terminus) (PubMed:18695040).

功能:

Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning.

亚细胞位置:

Cell projection Cilium membrane Multi-pass membrane protein Endoplasmic reticulum Cell membrane Cell surface and cilium localization requires GANAB.

数据库链接

UniGene:

Hs.181272

SMR:

Q13563

STRING:

9606.ENSP00000237596

KEGG:

hsa:5311

MIM:

173910

Pfam:

PF08016

Uniprot:

Q13563

相关产品

Mouse Pkd2 ELISA Kit

Bovine PKD2 ELISA Kit

Mouse Pkd2 CLIA Kit

Bovine PKD2 CLIA Kit

Mouse Pkd2 Protein

序列长度:

968

序列:

仅供参考，详细请咨询（services@eiaab.com）

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968:

STEGMEGAGG | NGSSNVHV

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

多克隆抗体PKD2可以申请产品的免费试用装吗？

我们不提供作测试目的的免费样品或试用装样品。如果某种抗体的性能与说明书上的数据说明不同，我们将提供换货或退款服务。如果抗体用于未测试的物种或应用，我们不提供换货或退款服务。EIAab产品的投诉期为6个月，逾期不予受理。

[2].

多克隆抗体PKD2说明书上的信息是及时更新的吗？

说明书包含了我们能获得的关于该产品的最新信息。当我们获得另外的信息时，说明书会实时更新，因此说明书绝不会过时。

[3].

如何选择合适的一抗？

请先确定您要检测的种属和使用的实验方法，然后查找相关产品，根据说明书上描述的“种属和应用”来确定合适的抗体。如果说明书中有明确您要检测的种属和实验方法均经过检测，则您可以放心地购买该产品。

[4].

多克隆抗体PKD2在其他物种或应用中测试过吗？

所有我们测试过抗体的物种和应用都会在说明书上说明。我们获取新信息后，就会立即更新物种和应用。

[5].

如何保存多克隆抗体PKD2？

我们建议始终按照说明书上的方法保存抗体。如果没有按照说明书上的说明保存，我们不能保证抗体的性能。

[6].

如何分装多克隆抗体PKD2？

请根据一次实验的常用量进行分装。每等份不应少于10μl；每等份的量越少，抗体储液浓度受蒸发和管壁吸附的影响越大。

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