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HJURP (基因名), Holliday junction recognition protein (蛋白名), hjurp_human.

产品名称:

HJURP Antibody

货号:

P2156Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

14-3-3-associated AKT substrate, Fetal liver-expressing gene 1 protein, Up-regulated in lung cancer 9, FAKTS, FLEG1, URLC9

序列号:

Q8NCD3

反应性:

human

免疫原:

Recombinant human HJURP protein ( R2156h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human HJURP Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical staining of human bone marrow using HJURP antibody.

通用注释

亚单元:

Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes (PubMed:16622419, PubMed:19410544, PubMed:19410545). Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4 (PubMed:21478274). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Interacts with 14-3-3 family members in a phosphorylation-dependent manner (PubMed:17256767). Interacts with MSH5 and NBN (PubMed:17823411).

功能:

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.

亚细胞位置:

Nucleus Nucleolus Chromosome Centromere Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.

数据库链接

UniGene:

Hs.532968

SMR:

Q8NCD3

STRING:

9606.ENSP00000414109

KEGG:

hsa:55355

MIM:

612667

Pfam: