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HDAC8 (基因名), Histone deacetylase 8 (蛋白名), hdac8_human.

产品名称:

HDAC8 Antibody

货号:

P1111Rb

商标:

EIAab^®

监管等级:

RUO

别名:

CDA07, HD8, HDACL1

序列号:

Q9BY41

反应性:

human,mouse,rat

免疫原:

Recombinant human HDAC8 protein ( R1111h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human HDAC8 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical analysis of formalin-fixed and paraffin-embedded human lung cancer tissue using HDAC8.

通用注释

亚单元:

Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3. Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation. Associates with alpha-SMA (smooth muscle alpha-actin).

功能:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

亚细胞位置:

Nucleus Cytoplasm Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

数据库链接

UniGene:

Hs.310536

SMR:

Q9BY41

STRING:

9606.ENSP00000362674

KEGG:

hsa:55869

MIM: