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CSK (基因名), Tyrosine-protein kinase CSK (蛋白名), csk_human.

产品名称:

CSK Antibody

货号:

P11982Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

C-Src kinase, Protein-tyrosine kinase CYL

序列号:

P41240

反应性:

human

免疫原:

Recombinant human CSK protein ( R11982h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Signal Transduction

规格 & 价格:

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Human CSK Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

Immunohistochemical of paraffin-embedded human lung using CSK antibody at dilution of 1:100.

通用注释

亚单元:

Homodimer (via SH3-domain) (PubMed:19888460). Interacts with PTPN22 (PubMed:15208781). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases (PubMed:11433379, PubMed:10790433, PubMed:14610046, PubMed:10838081). Interacts with SRCIN1 (PubMed:17525734). Interacts with RHOH (PubMed:20851766). Interacts (via SH2 domain) with SCIMP (PubMed:21930792).

功能:

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

亚细胞位置:

Cytoplasm Cell membrane Mainly cytoplasmic, also present in lipid rafts.

数据库链接

UniGene:

Hs.77793

SMR:

P41240

STRING:

9606.ENSP00000220003

KEGG:

hsa:1445

MIM: