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CNTN1 (基因名), Contactin-1 (蛋白名), cntn1_human.
产品名称:

CNTN1 Antibody

货号:

P15020Rb

商标:
EIAab®
监管等级:
别名:

Glycoprotein gp135, Neural cell surface protein F3

序列号:
Q12860
反应性:
human,mouse,rat
免疫原:
Recombinant human CNTN1 protein ( R15020h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Neurosciences
Human CNTN1 Polyclonal Antibody
规格 & 价格: cart
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Human CNTN1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Immunohistochemical analysis of CNTN1 was detected in immersion fixed paraffin-embedded sections of human dorsal root ganglia using 10 μg/mL Anti- CNTN1 Polyclonal Antibody.
通用注释


亚单元:
Monomer. Interacts with CNTNAP1 in cis form (By similarity). Binds to the carbonic-anhydrase like domain of PTPRZ1 (PubMed:20133774). Interacts with NOTCH1 and TNR. Detected in a complex with NRCAM and PTPRB.


功能:
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.


亚细胞位置:
Isoform 2 Cell membrane Lipid-anchor GPI-anchor Extracellular side


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