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CHEK1 (基因名), Serine/threonine-protein kinase Chk1 (蛋白名), chk1_human.

产品名称:

CHEK1 Antibody

货号:

P11379Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, CHK1

序列号:

O14757

反应性:

human

免疫原:

Recombinant human CHEK1 protein ( R11379h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human CHEK1 Polyclonal Antibody

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产品说明书

数据表:

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R&D 技术数据

Immunohistochemical of paraffin-embedded mouse colon using CHEK1 antibody at dilution of 1:20.

通用注释

亚单元:

Interacts (phosphorylated by ATR) with RAD51. Interacts with and phosphorylates CLSPN, an adapter protein that regulates the ATR-dependent phosphorylation of CHEK1. Interacts with BRCA1. Interacts with and phosphorylates CDC25A, CDC25B and CDC25C. Interacts with FBXO6, which regulates CHEK1. Interacts with PPM1D, which regulates CHEK1 through dephosphorylation. Interacts with TIMELESS; DNA damage-dependent. Interacts with FEM1B; activates CHEK1 in response to stress. Interacts with TLK1. Interacts with XPO1 and YWHAZ. Isoform 1 associates with isoform 2, the interaction is disrupted upon phosphorylation by ATR. Interacts with CDK5RAP3; antagonizes CHEK1 (PubMed:19223857).

功能:

Isoform 2: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition.

亚细胞位置:

Nucleus Cytoplasm Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Nuclear export is mediated at least in part by XPO1/CRM1. Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B.

数据库链接

UniGene:

Hs.24529

SMR:

O14757

STRING:

9606.ENSP00000388648

KEGG:

hsa:1111

MIM:

603078

Pfam: