CEACAM1 (基因名), Carcinoembryonic antigen-related cell adhesion molecule 1 (蛋白名), ceam1_human.
产品名称:
CEACAM1 Antibody
货号:
P13767Rb-h
商标:
EIAab®
监管等级:
别名:
Biliary glycoprotein 1, BGP-1, CD66a, BGP, BGP1
序列号:
P13688
反应性:
human
免疫原:
Recombinant human CEACAM1 protein ( R13767h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Immunology
R&D 技术数据
通用注释
亚单元:
Monomer. Oligomer. Heterodimer. Homodimer. Cis-dimer/oligomer (via Ig-like C2-type and/or via cytoplasmic domains); induced by trans-homophilic cell adhesion through an allosteric mechanism transmitted by the Ig-like V-type domain, and is regulated by intracellular calcium and calmodulin. Interacts (via cytoplasmic domain) with calmodulin in a calcium dependent manner; reduces homophilic cell adhesion through dissociation of dimer (By similarity). Isoform 1 interacts (via cytoplasmic domain) with PTPN11 (preferentially) and PTPN6; cis-homodimer form is preferred; this interaction is decreased by formation of Isoform 1 /Isoform 8 cis-heterodimers and is dependent on the monomer/dimer equilibrium; this interaction is phosphorylation-dependent (PubMed:23696226). Isoform 1 interacts with LYN (By similarity). Isoform 1 interacts (via cytoplasmic domain) with SRC (via SH2 domain); this interaction is regulated by trans-homophilic cell adhesion (PubMed:7478590). Isoform 1 interacts (via cytoplasmic domain) with LCK; mediates phosphorylation at Tyr-493 and Tyr-520 resulting in PTPN6 association. Isoform 1 interacts with PTPN6; this interaction is phosphorylation-dependent and causes a profound decrease in TCR stimulation-induced CD247 and ZAP70 phosphorylation. Isoform 1 interacts with TCR/CD3 complex through TCR beta chain and CD3E; colocalizes at the cell surface and upon stimulation of the TCR/CD3 complex recuits PTPN6 in the TCR/CD3 complex, resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Isoform 1 interacts (via cytoplasmic domain) with SHC1 (via SH2 domain); SHC1 mediates interaction with INSR or EGFR in a Ser-508 phosphorylation-dependent manner (By similarity). Isoform 1 interacts with EGFR; the interaction is indirect (PubMed:15467833). Isoform 1 interacts with CSF3R; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Isoform 1 (phosphorylated form) interacts with TLR4 and SYK; recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, leading to a reduction of the inflammasome activity (By similarity). Isoform 1 interacts with FLNA; inhibits cell migration and cell scattering by interfering with the interaction of FLNA with RALA (PubMed:16291724). Isoform 1 interacts (via cytoplasmic domain) with PXN; the interaction is phosphotyrosyl-dependent (PubMed:11035932). Isoform 1 interacts with KLRK1; recruits PTPN6 that dephosphorylates VAV1 (PubMed:23696226). Isoform 1 interacts with CEACAM8 (PubMed:11994468). Isoform 1 interacts with FASN; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity (By similarity). Interacts (via Ig-like V-type) with HAVCR2 (via Ig-like V-type); facilitates the maturation and cell surface expression of HAVCR2 thereby regulating T cell tolerance induction (PubMed:25363763). Isoform 8 interacts (via the cytoplasmic domain) with ANXA2; this interaction is regulated by phosphorylation and appears in the AIIt complex (PubMed:14522961). Interacts (via Lewis X moieties) with CD209 (via C-type lectin domain); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils (PubMed:16246332).
功能:
Isoform 8: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens.
亚细胞位置:
Cell projection
Microvillus membrane
Single-pass type I membrane protein
Apical cell membrane
Single-pass type I membrane protein
Colocalizes with CEACAM20 at the apical brush border of intestinal cells.
该产品尚未在任何出版物中被引用。
[1].
多克隆抗体CEACAM1可以申请产品的免费试用装吗?
我们不提供作测试目的的免费样品或试用装样品。如果某种抗体的性能与说明书上的数据说明不同,我们将提供换货或退款服务。如果抗体用于未测试的物种或应用,我们不提供换货或退款服务。EIAab产品的投诉期为6个月,逾期不予受理。
[2].
多克隆抗体CEACAM1说明书上的信息是及时更新的吗?
说明书包含了我们能获得的关于该产品的最新信息。当我们获得另外的信息时,说明书会实时更新,因此说明书绝不会过时。
[3].
如何选择合适的一抗?
请先确定您要检测的种属和使用的实验方法,然后查找相关产品,根据说明书上描述的“种属和应用”来确定合适的抗体。如果说明书中有明确您要检测的种属和实验方法均经过检测,则您可以放心地购买该产品。
[4].
多克隆抗体CEACAM1在其他物种或应用中测试过吗?
所有我们测试过抗体的物种和应用都会在说明书上说明。我们获取新信息后,就会立即更新物种和应用。
[5].
如何保存多克隆抗体CEACAM1?
我们建议始终按照说明书上的方法保存抗体。如果没有按照说明书上的说明保存,我们不能保证抗体的性能。
[6].
如何分装多克隆抗体CEACAM1?
请根据一次实验的常用量进行分装。每等份不应少于10μl;每等份的量越少,抗体储液浓度受蒸发和管壁吸附的影响越大。
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