首页 > 一抗 > CDK5R1 Antibody

CDK5R1 (基因名), Cyclin-dependent kinase 5 activator 1 (蛋白名), cd5r1_human.

产品名称:

CDK5R1 Antibody

货号:

P15082Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, CDK5 activator 1, CDK5R, NCK5A

序列号:

Q15078

反应性:

human

免疫原:

Recombinant human CDK5R1 protein ( R15082h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human CDK5R1 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical analysis of formalin-fixed paraffin embedded human brain tissue using CDK5R1 antibody.

通用注释

亚单元:

Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4 (By similarity). Interacts with RASGRF2. The complex p35/CDK5 interacts with CLOCK.

功能:

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

亚细胞位置:

Cyclin-dependent kinase 5 activator 1, p25 Nucleus Cytoplasm Perinuclear region The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.

数据库链接

UniGene:

Hs.500015

SMR:

Q15078

STRING:

9606.ENSP00000318486

KEGG:

hsa:8851

MIM:

603460

Pfam: