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CDKN2A (基因名), Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (蛋白名), cd2a1_human.

产品名称:

CDKN2A Antibody

货号:

P0794Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Cyclin-dependent kinase 4 inhibitor A, Multiple tumor suppressor 1, p16-INK4a, CDK4I, MTS-1, p16-INK4, p16INK4A, CDKN2, MTS1

序列号:

P42771

反应性:

human

免疫原:

Recombinant human CDKN2A Protein (R0794h)

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human CDKN2A Polyclonal Antibody

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产品说明书

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R&D 技术数据

Mouse lung tissue lysate was subjected to SDS-PAGE followed by Western Blot with CDKN2A antibody at dilution of 1:300 (Observed molecular weight is about110 kDa)

Immunohistochemistry of CDKN2A in human colon tissue with CDKN2A antibody at 8 ug/ml.

通用注释

亚单元:

Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts (isoforms 1,2 and 4) with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.

功能:

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

亚细胞位置:

Cytoplasm Nucleus

数据库链接

Uniprot:

P42771

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