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CCN1 (基因名), CCN family member 1 (蛋白名), ccn1_human.

产品名称:

CCN1 Antibody

货号:

P0494Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Cellular communication network factor 1, Cysteine-rich angiogenic inducer 61, Insulin-like growth factor-binding protein 10, Protein CYR61, Protein GIG1, IBP-10, CYR61, GIG1, IGFBP10

序列号:

O00622

反应性:

human,rat

免疫原:

corresponding to a sequence mapping at the 171-381aa of O00622

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cardiovascular

规格 & 价格:

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Human CCN1 Polyclonal Antibody

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产品说明书

数据表:

MSDS:

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R&D 技术数据

CYR61 antibody detects CYR61 protein at cytoplasm in rat intestine by immunohistochemical analysis. CYR61 antibody diluted at 1:300.

通用注释

亚单元:

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

功能:

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.8867

SMR:

O00622

STRING:

9606.ENSP00000398736

KEGG:

hsa:3491

MIM: