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CDH2 (基因名), Cadherin-2 (蛋白名), cadh2_human.
产品名称:

CDH2 Antibody

货号:

P1481Rb-h

商标:
EIAab®
监管等级:
别名:

CDw325, Neural cadherin, N-cadherin, CD325, CDHN, NCAD

序列号:
P19022
反应性:
human
免疫原:
Recombinant human CDH2 protein ( R1481h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human CDH2 Polyclonal Antibody
规格 & 价格: cart
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Human CDH2 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
CDH2 antibody detects CDH2 protein at membrane on hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded human hepatoma. N-Cadherin antibody dilution: 1:200.
通用注释


亚单元:
Interacts with CDCP1 (PubMed:16007225). Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). May interact with OBSCN (via protein kinase domain 2).


功能:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Cell membrane Sarcolemma Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes.


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