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Ythdc2 (基因名), 3'-5' RNA helicase YTHDC2 (蛋白名), ytdc2_mouse.
产品名称:

Mouse Ythdc2/ 3'-5' RNA helicase YTHDC2 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Keen to exit meiosis leaving testes under-populated protein, YTH domain-containing protein C2, Ketu, mYTHDC2

检测方法:
ELISA
特异性:
Natural and recombinant mouse 3'-5' RNA helicase YTHDC2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Epigenetics
Mouse Ythdc2 ELISA Kit
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Mouse Ythdc2 ELISA Kit
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通用注释


亚单元:
Interacts with MEIOC; binds transcripts that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally (PubMed:28380054, PubMed:29087293). Interacts (via ANK repeats) with XRN1 (By similarity).


功能:
3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:28380054, PubMed:28809393, PubMed:29087293, PubMed:29033321, PubMed:29360036). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:29360036). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (PubMed:29033321). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (PubMed:28809393, PubMed:29033321).


亚细胞位置:
Cytoplasm


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