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Xrcc2 (基因名), DNA repair protein XRCC2 (蛋白名), xrcc2_mouse.
产品名称:

Mouse Xrcc2/ DNA repair protein XRCC2 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

X-ray repair cross-complementing protein 2

检测方法:
ELISA
特异性:
Natural and recombinant mouse DNA repair protein XRCC2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Mouse Xrcc2 ELISA Kit
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Mouse Xrcc2 ELISA Kit
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通用注释


亚单元:
Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA.


功能:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.


亚细胞位置:
Nucleus


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