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Xpot (基因名), Exportin-T (蛋白名), xpot_mouse.
产品名称:

Mouse Xpot/ Exportin-T ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Exportin(tRNA), tRNA exportin

检测方法:
ELISA
特异性:
Natural and recombinant mouse Exportin-T
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Xpot ELISA Kit
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Mouse Xpot ELISA Kit
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通用注释


亚单元:
Found in a complex with XPOT, Ran and tRNA. Probably found in a complex with nucleoporins. Interacts with Ran and tRNA in a GTP-dependent manner.


功能:
Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.


亚细胞位置:
Nucleus Cytoplasm Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm (By similarity).


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