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XPO4 (基因名), Exportin-4 (蛋白名), xpo4_human.
产品名称:

Human XPO4/ Exportin-4 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Exp4, KIAA1721

检测方法:
ELISA
特异性:
Natural and recombinant human Exportin-4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human XPO4 ELISA Kit
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Human XPO4 ELISA Kit
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通用注释


亚单元:
Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner.


功能:
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.


亚细胞位置:
Cytoplasm Nucleus Shuttles between the nucleus and the cytoplasm.


该产品尚未在任何出版物中被引用。
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