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XBP1 (基因名), X-box-binding protein 1 (蛋白名), xbp1_bovin.
产品名称:

Bovine XBP1/ X-box-binding protein 1 ELISA Kit
X-盒结合蛋白1

货号:

E9143b

商标:
EIAab®
监管等级:
别名:

XBP-1

检测方法:
ELISA
特异性:
Natural and recombinant bovine X-box-binding protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine XBP1 ELISA Kit
规格 & 价格: cart
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Bovine XBP1 ELISA Kit
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产品说明书
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通用注释


亚单元:
Isoform 1 interacts with HM13. Isoform 1 interacts with RNF139; the interaction induces ubiquitination and degradation of isoform 1. Isoform 1 interacts (via luminal domain) with DERL1; the interaction obviates the need for ectodomain shedding prior HM13/SPP-mediated XBP1 isoform 1 cleavage. Isoform 1 interacts with HDAC3 and AKT1; the interactions occur in endothelial cell (EC) under disturbed flow. Isoform 1 interacts with the oncoprotein FOS. Interacts with SIRT1.


功能:
Isoform 1: Acts as a weak transcriptional factor. Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress. Binds to the ER stress response element (ERSE) upon ER stress. Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences. Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner. Binds to the CDH5/VE-cadherin gene promoter region.


亚细胞位置:
Isoform 1 Nucleus Cytoplasm Endoplasmic reticulum membrane Single-pass type II membrane protein Endoplasmic reticulum membrane Peripheral membrane protein Membrane Peripheral membrane protein Shows no preferential localization to either the nucleus or the cytoplasm. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane.


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