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WNK1 (基因名), Serine/threonine-protein kinase WNK1 (蛋白名), wnk1_pig.
产品名称:

Pig WNK1/ Serine/threonine-protein kinase WNK1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

HSN2

检测方法:
ELISA
特异性:
Natural and recombinant pig Serine/threonine-protein kinase WNK1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Pig WNK1 ELISA Kit
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Pig WNK1 ELISA Kit
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通用注释


亚单元:
Interacts with SYT2. Interacts with KLHL3, WNK3 and WNK4.


功能:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。
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