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TDP2 (基因名), Tyrosyl-DNA phosphodiesterase 2 (蛋白名), tydp2_chick.
产品名称:

Chicken TDP2/ Tyrosyl-DNA phosphodiesterase 2 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

5'-tyrosyl-DNA phosphodiesterase, 5'-Tyr-DNA phosphodiesterase, Tyr-DNA phosphodiesterase 2

检测方法:
ELISA
特异性:
Natural and recombinant chicken Tyrosyl-DNA phosphodiesterase 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Chicken TDP2 ELISA Kit
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Chicken TDP2 ELISA Kit
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亚单元:
N/A


功能:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1.


亚细胞位置:
Nucleus Nucleus PML body


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