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THBS1 (基因名), Thrombospondin-1 (蛋白名), tsp1_bovin.
产品名称:

Bovine THBS1/ Thrombospondin-1 ELISA Kit
血小板反应蛋白1

货号:

E0611b

商标:
EIAab®
监管等级:
别名:

Glycoprotein G, TSP-1, TSP1

检测方法:
ELISA
特异性:
Natural and recombinant bovine Thrombospondin-1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine THBS1 ELISA Kit
规格 & 价格: cart
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Bovine THBS1 ELISA Kit
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通用注释


亚单元:
Homotrimer; disulfide-linked (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Binds heparin. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Interacts with ATF6 (via lumenal domain) (By similarity).


功能:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties (By similarity). May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).


亚细胞位置:
Secreted Cell surface Secreted Extracellular space Extracellular matrix Endoplasmic reticulum Sarcoplasmic reticulum Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+). Incorporated into the extracellular matrix of fibroblasts. Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response.


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