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TMEM59 (基因名), Transmembrane protein 59 (蛋白名), tmm59_bovin.
产品名称:

Bovine TMEM59/ Transmembrane protein 59 ELISA Kit

货号:

E15912b

商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant bovine Transmembrane protein 59
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine TMEM59 ELISA Kit
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Bovine TMEM59 ELISA Kit
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通用注释


亚单元:
Interacts with ATG16L1 (via WD repeats).


功能:
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.


亚细胞位置:
Late endosome membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Cell membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.


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