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TMEM108 (基因名), Transmembrane protein 108 (蛋白名), tm108_bovin.
产品名称:

Bovine TMEM108/ Transmembrane protein 108 ELISA Kit

货号:

E15756b

商标:
EIAab®
监管等级:
别名:

Retrolinkin

检测方法:
ELISA
特异性:
Natural and recombinant bovine Transmembrane protein 108
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine TMEM108 ELISA Kit
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Bovine TMEM108 ELISA Kit
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亚单元:
Interacts with DST (isoform 1). Interacts with SH3GL2. Interacts (via N-terminus) with CYFIP1 and CYFIP2; the interactions associate TMEM108 with the WAVE1 complex.


功能:
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.


亚细胞位置:
Membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Endosome membrane Cell projection Axon Cell projection Dendrite Early endosome


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