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TLR3 (基因名), Toll-like receptor 3 (蛋白名), tlr3_bovin.
产品名称:

Bovine TLR3/ Toll-like receptor 3 ELISA Kit
Toll样受体3

货号:

E1989b

商标:
EIAab®
监管等级:
别名:

CD283

检测方法:
ELISA
特异性:
Natural and recombinant bovine Toll-like receptor 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Immunology
Bovine TLR3 ELISA Kit
规格 & 价格: cart
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Bovine TLR3 ELISA Kit
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通用注释


亚单元:
Monomer and homodimer; dimerization is triggered by ligand-binding, the signaling unit is composed of one ds-RNA of around 40 bp and two TLR3 molecules, and lateral clustering of signaling units along the length of the ds-RNA ligand is required for TLR3 signal transduction. Interacts (via transmembrane domain) with UNC93B1; the interaction is required for transport from the ER to the endosomes. Interacts with TICAM1 (via the TIR domain) in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1. Interacts with SRC; upon binding of double-stranded RNA. The tyrosine-phosphorylated form (via TIR domain) interacts with WDFY1 (via WD repeat 2) in response to poly(I:C).


功能:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.


亚细胞位置:
Endoplasmic reticulum membrane Single-pass type I membrane protein Endosome membrane Early endosome


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