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Tnr (基因名), Tenascin-R (蛋白名), tenr_mouse.
产品名称:

Mouse Tnr/ Tenascin-R ELISA Kit
Tenascin-R

货号:

E1328m

商标:
EIAab®
监管等级:
别名:

Janusin, Neural recognition molecule J1-160/180, Restrictin, TN-R

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
1.56-100ng/mL
灵敏度:
0.792ng/mL
特异性:
Natural and recombinant mouse Tenascin-R
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Mouse Tnr ELISA Kit
规格 & 价格: cart
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Mouse Tnr ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with BCAN and ACAN in a calcium-dependent manner. Interacts with SCN2B, PTPRZ1, and CSPG3 (By similarity). Forms oligomers. Isoforms 1 and 2 form respectively trimeric (tribrachion) and dimeric kink-armed rodlike structures, which are linked by disulfide bridges. Interacts with CNTN1, TNC and FN1.


功能:
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance.


亚细胞位置:
Secreted Extracellular space Extracellular matrix


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