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TERF2IP (基因名), Telomeric repeat-binding factor 2-interacting protein 1 (蛋白名), te2ip_bovin.
产品名称:

Bovine TERF2IP/ Telomeric repeat-binding factor 2-interacting protein 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Repressor/activator protein 1 homolog, RAP1 homolog, TERF2-interacting telomeric protein 1, RAP1

检测方法:
ELISA
特异性:
Natural and recombinant bovine Telomeric repeat-binding factor 2-interacting protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine TERF2IP ELISA Kit
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Bovine TERF2IP ELISA Kit
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产品说明书
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通用注释


亚单元:
Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12. Interacts with TERF2; the interaction is direct.


功能:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.


亚细胞位置:
Nucleus Cytoplasm Chromosome Chromosome Telomere Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.


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