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TCIM (基因名), Transcriptional and immune response regulator (蛋白名), tcim_bovin.
产品名称:

Bovine TCIM/ Transcriptional and immune response regulator ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

TC1

检测方法:
ELISA
特异性:
Natural and recombinant bovine Transcriptional and immune response regulator
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine TCIM ELISA Kit
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Bovine TCIM ELISA Kit
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产品说明书
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通用注释


亚单元:
Monomer. Interacts with NOTCH2 (via ANK repeats), the interaction inhibits the nuclear translocation of NOTCH2 N2ICD. Interacts (C-terminus) with CBY1 (C-terminus), TCIM competes with CTNNB1 for the interaction with CBY1.


功能:
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity).


亚细胞位置:
Cytoplasm Nucleus Nucleolus Nucleus speckle Nucleus Localizes in nucleus speckles in presence of CBY1. Translocates to the nucleus upon cellular stress such as H(2)O(2).


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